| 2021-09-04 15:00:4604.09.21 |  Eislöwen vs. Düsseldorf | 5 - 3 | | JOYNEXT Arena |
| 2021-09-04 18:30:1404.09.21 | Nürnberg vs. Iserlohn | 5 - 2 | | JOYNEXT Arena |
| 2021-09-05 15:00:3505.09.21 | Düsseldorf vs. Iserlohn | 5 - 2 | | JOYNEXT Arena |
| 2021-09-05 18:30:3105.09.21 | Eislöwen vs. Nürnberg | 1 - 4 | | JOYNEXT Arena |
| 2021-09-11 17:00:2811.09.21 | Selb vs. Eislöwen | 3 - 4 | | NETZSCH-Arena |
| 2021-09-12 16:00:5512.09.21 | Erfurt vs. Eislöwen | 0 - 4 | | Eissportzentrum Erfurt |
| 2021-09-17 20:00:4817.09.21 | Bayreuth vs. Eislöwen | 3 - 2 | | Städtisches Kunsteisstadion Bayreuth |
| 2021-09-24 19:30:0724.09.21 | Weißwasser vs. Eislöwen | 1 - 5 | | weeEisArena Weißwasser |
| 2021-09-26 17:00:3726.09.21 | Eislöwen vs. Bayreuth | 2 - 3 | | JOYNEXT Arena |
| 2021-10-01 19:30:3001.10.21 | Weißwasser vs. Eislöwen | 3 - 2 OT | DEL2 | weeEisArena Weißwasser |
| 2021-10-03 16:00:0503.10.21 | Eislöwen vs. Bayreuth | 7 - 2 | DEL2 | JOYNEXT Arena |
| 2021-10-08 20:00:5708.10.21 | Heilbronn vs. Eislöwen | 4 - 0 | DEL2 | Eishalle Heilbronn |
| 2021-10-10 17:00:4510.10.21 | Eislöwen vs. Kaufbeuren | 5 - 4 | DEL2 | JOYNEXT Arena |
| 2021-10-15 19:30:5415.10.21 | Frankfurt vs. Eislöwen | 5 - 1 | DEL2 | Eissporthalle Frankfurt |
| 2021-10-17 17:00:4917.10.21 | Eislöwen vs. Freiburg | 3 - 4 SO | DEL2 | JOYNEXT Arena |
| 2021-10-22 20:00:5822.10.21 | Ravensburg vs. Eislöwen | 2 - 1 OT | DEL2 | CHG Arena |
| 2021-10-24 17:00:0124.10.21 | Eislöwen vs. Bad Tölz | 5 - 4 | DEL2 | JOYNEXT Arena |
| 2021-10-29 19:30:0429.10.21 | Eislöwen vs. Selb | 6 - 2 | DEL2 | JOYNEXT Arena |
| 2021-10-31 18:30:0631.10.21 | Bad Nauheim vs. Eislöwen | 1 - 2 | DEL2 | Colonel-Knight-Stadion |
| 2021-11-02 19:30:2102.11.21 | Eislöwen vs. Crimmitschau | 3 - 2 OT | DEL2 | JOYNEXT Arena |
| 2021-11-05 19:30:2505.11.21 | Eislöwen vs. Weißwasser | 4 - 1 | DEL2 | JOYNEXT Arena |
| 2021-11-07 18:30:2907.11.21 | Kassel vs. Eislöwen | 7 - 6 | DEL2 | Kasseler Eissporthalle |
| 2021-11-16 19:30:5416.11.21 | Landshut vs. Eislöwen | 1 - 6 | DEL2 | Fanatec Arena |
| 2021-11-19 19:30:5719.11.21 | Eislöwen vs. Heilbronn | 4 - 3 | DEL2 | JOYNEXT Arena |
| 2021-11-21 17:00:0721.11.21 | Kaufbeuren vs. Eislöwen | 2 - 4 | DEL2 | erdgas schwaben arena |
| 2021-11-26 19:30:2726.11.21 | Eislöwen vs. Frankfurt | 4 - 2 | DEL2 | JOYNEXT Arena |
| 2021-11-28 18:30:4828.11.21 | Freiburg vs. Eislöwen | 2 - 1 | DEL2 | Echte Helden Arena |
| 2021-12-03 19:30:0903.12.21 | Eislöwen vs. Ravensburg | 3 - 4 SO | DEL2 | JOYNEXT Arena |
| 2021-12-05 18:30:2105.12.21 | Bad Tölz vs. Eislöwen | 4 - 5 OT | DEL2 | RSS Arena |
| 2021-12-07 20:00:3307.12.21 | Crimmitschau vs. Eislöwen | 3 - 4 SO | DEL2 | Kunsteisstadion im Sahnpark |
| 2021-12-10 19:30:3710.12.21 | Selb vs. Eislöwen | 0 - 5 | DEL2 | NETZSCH-Arena |
| 2021-12-12 16:00:4012.12.21 | Eislöwen vs. Bad Nauheim | 2 - 3 SO | DEL2 | JOYNEXT Arena |
| 2021-12-17 19:30:4517.12.21 | Eislöwen vs. Kassel | 6 - 0 | DEL2 | JOYNEXT Arena |
| 2021-12-19 17:00:0019.12.21 | Bayreuth vs. Eislöwen | 0 - 3 | DEL2 | Städtisches Kunsteisstadion Bayreuth |
| 2021-12-22 19:30:0422.12.21 | Eislöwen vs. Landshut | 3 - 2 OT | DEL2 | JOYNEXT Arena |
| 2021-12-26 17:00:2026.12.21 | Eislöwen vs. Bayreuth | 5 - 6 | DEL2 | JOYNEXT Arena |
| 2021-12-28 19:30:2228.12.21 | Weißwasser vs. Eislöwen | 1 - 3 | DEL2 | weeEisArena Weißwasser |
| 2021-12-30 19:30:2730.12.21 | Eislöwen vs. Kaufbeuren | 5 - 2 | DEL2 | JOYNEXT Arena |
| 2022-01-02 16:00:2202.01.22 | Heilbronn vs. Eislöwen | 2 - 5 | DEL2 | Eishalle Heilbronn |
| 2022-01-05 19:30:5305.01.22 | Selb vs. Eislöwen | 2 - 7 | DEL2 | NETZSCH-Arena |
| 2022-01-07 19:30:1407.01.22 | Eislöwen vs. Bad Tölz | 4 - 1 | DEL2 | JOYNEXT Arena |
| 2022-01-14 19:30:0314.01.22 | Bad Nauheim vs. Eislöwen | 2 - 1 OT | DEL2 | Colonel-Knight-Stadion |
| 2022-01-16 16:00:1316.01.22 | Eislöwen vs. Selb | 6 - 0 | DEL2 | JOYNEXT Arena |
| 2022-01-18 19:30:5818.01.22 | Frankfurt vs. Eislöwen | 1 - 4 | DEL2 | Eissporthalle Frankfurt |
| 2022-01-21 19:30:4321.01.22 | Landshut vs. Eislöwen | 19:30:4319:30 | DEL2 | Fanatec Arena |
| 2022-01-23 17:00:3623.01.22 | |
